TLR4 regulates pulmonary vascular homeostasis and remodeling via redox signaling
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چکیده
منابع مشابه
TLR4 regulates pulmonary vascular homeostasis and remodeling via redox signaling.
Pulmonary arterial hypertension (PAH) contributes to morbidity and mortality of patients with lung and heart diseases. We demonstrated that hypoxia induced PAH and increased pulmonary arterial wall thickness in wild-type mice. Mice deficient in toll-like receptor 4 (TLR4-/-) spontaneously developed PAH, which was not further enhanced by hypoxia. Echocardiography determined right ventricular hyp...
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ژورنال
عنوان ژورنال: Frontiers in Bioscience
سال: 2016
ISSN: 1093-9946,1093-4715
DOI: 10.2741/4396